Association of miR-146a rs2910164 and miR-27a rs895819 polymorphisms with type 2 diabetes susceptibility: A Meta-Analysis

Background and Aim: Several investigations have evaluated the association of miR-146a rs2910164 and miR-27a rs895819 single-nucleotide polymorphisms with susceptibility to type 2 diabetes (T2D). However, the findings are conflicting and inconclusive. Therefore, this meta-analysis performed to investigate the association between these polymorphisms and T2D risk. Methods: Studies were identified via a systematic search of the PubMed, Google scholar, Scopus and Sciencedirect databases up to June 2, 2019. A total of 2069 cases and 1947 controls for miR-146a rs2910164 and 1090 T2D and 966 non-diabetic subjects for miR-27a rs895819 were included in this meta-analysis by pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: Our results indicated that there were no significant association between miR-146a rs2910164 and miR-27a rs895819 variants and the T2D risk (P>0.05). Conclusion: This meta-analysis showed that these polymorphisms were not significantly associated with T2D. Further studies with large sample size in more diverse geographically regions are needed to improve these findings.